2 However, this risk stratification is incomplete. The clinical decision regarding use of adjuvant therapy has been based on lymph node status and other clinic pathological risk factors (eg grade or presence of obstruction or perforation). 1 Traditionally, treatment and prognostication have been based on American Joint Committee on Cancer tumor–node-metastasis staging, relying on the extent of radiographically evident disease locoregional disease is treated primarily with surgery, with or without adjuvant chemotherapy, and metastatic disease is primarily treated with systemic therapy. Colorectal cancer (CRC) remains the third most common cancer and second most common cause of cancer death in the United States.
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